Stopping Cancer at the Start: Looking for New Drugs to Block Tumor Initiation
When a tumor-initiating cell experiences isolation stress, it begins expressing a membrane receptor called LPAR4. This leads the cell to produce a new extracellular matrix full of a protein called fibronectin (FN1), which keeps the cell safe and signals other cells to join. UC San Diego Health Sciences
When cancer cells first form, they become separated from the other cells around them, which starves them of critical oxygen and nutrients. Most cells do not survive this isolation stress, but a s
When cancer cells first form, they become separated from the other cells around them, which starves them of critical oxygen and nutrients. Most cells do not survive this isolation stress, but a s
