Press Releases

Explore a featured selection of my press releases on research and clinical news

Stem Cell Therapy Rescues Symptoms of Alzheimer’s Disease

In the ongoing search for a cure for Alzheimer’s disease, a burgeoning branch of medicine is bringing new hope. Stem cell therapies are already being used to treat various cancers and disorders of the blood and immune system. In a new proof-of-concept study, scientists at University of California San Diego show stem cell transplants may also be a promising therapeutic against Alzheimer’s. In the study, published August 8, 2023 in Cell Reports, the researchers demonstrate that transplanting hemat

Artificial Intelligence Aids Discovery of Super Tight-Binding Antibodies

Scientists at University of California San Diego School of Medicine have developed an artificial intelligence (AI)-based strategy for discovering high-affinity antibody drugs.

In the study, published January 28, 2023 in Nature Communications, researchers used the approach to identify a new antibody that binds a major cancer target 17-fold tighter than an existing antibody drug. The authors say the pipeline could accelerate the discovery of novel drugs against cancer and other diseases such as C

LJI scientists uncover the structure and function of Inmazeb, the first FDA-approved drug for Ebola virus infection

In the cover story of the latest issue of Cell Host & Microbe, LJI researchers present a high-resolution, 3D structure of the three antibodies as they bind to the Ebola virus glycoprotein (the viral protein that launches Ebola virus infection). The model reveals new information about both the drug and the virus, and how their interaction fights infection and protects against future viral mutations.

Stress-Tolerant Cells Drive Tumor Initiation in Pancreatic Cancer

Researchers at University of California San Diego School of Medicine have discovered a molecular pathway critical to the initiation of pancreatic tumors. The mechanism could also contribute to the disease’s high resistance to chemotherapy and its propensity for metastasis. The study, published on January 16, 2022 in Nature Cell Biology, found that pancreatic tumor-initiating cells must first overcome local ‘isolation stress’ by creating their own tumor-promoting microenvironment, and then recrui

Tissue-Specific Immunity May Be the Future, if We Can First Learn its Rules

After experiencing an infection, the immune system leaves behind memory T cells, which maintain a long-lasting molecular memory of the pathogen and are ready to sound the alarm if it ever returns. While some memory T cells are designed to circulate through the bloodstream and provide whole-body protection, others reside in specific organs and are specialized to fight the pathogens that target that part of the body. These T cells can provide life-long immunity at the target tissue, but can also c

Enzyme Drives Cognitive Decline in Mice, Provides New Target for Alzheimer’s

“We were surprised to find that just a slight increase in PKCα activity was enough to recreate the Alzheimer’s phenotype in a mouse,” said senior author Alexandra C. Newton, PhD, Distinguished Professor of Pharmacology at UC San Diego School of Medicine. “This is an amazing example of the importance of homeostasis in biology — even minor tweaks in kinase activity can result in pathology if the effects are allowed to accumulate over a lifetime.”

To confirm whether similar enzymatic changes could
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